Article

Rational Prediction of PROTAC-compatible Protein-Protein Interfaces by Molecular Docking

2023-02-16

Abstract excerpt

Proteolysis targeting chimeras (PROTACS) are heterobifunctional ligands that mediate the interaction between a protein target and an E3 ligase, resulting in a ternary complex whose interaction with the ubiquitination machinery leads to target degradation. This technology is emerging as an exciting new avenue for therapeutic development, with several PROTACS currently undergoing clinical trials targeting cancer. He...

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Literature Corpus work: 35044616-bae9-5d0f-9c5a-68ac63db5b82
DOI: 10.1101/2023.02.16.528819

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