Article

Neuron-type specific aging-rate reveals age decelerating interventions preventing neurodegeneration

2024-05-29

Abstract excerpt

<title>Abstract</title> <p> <bold>Different types of neurons show distinct susceptibility to age-dependent functional decline and degeneration and are linked to different types of neurodegenerative disorders. The underlying reasons for different aging trajectories of distinct neuron types are poorly understood. Here, we employ aging clocks to assess whether distinct neurons differ in their biological age traject...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a9baba8-93b7-5487-9328-79f9639f6184
DOI: 10.21203/rs.3.rs-4360587/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuron-type specific aging-rate reveals age decelerating interventions preventing neurodegenerationDOI 10.21203/rs.3.rs-4360587/v1Read

Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis.Semantic proximity Read

Neuronal aging: learning from C. elegansSemantic proximity Read

Systematic Review of Caenorhabditis elegans Models for Mechanism Research and Drug Discovery in Parkinson’s DiseaseSemantic proximity Read

Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans.Semantic proximity Read

Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system.Semantic proximity Read

Caenorhabditis elegans as a Model System to Study Human Neurodegenerative DisordersSemantic proximity Read

A linear regression model predicts human brain ageing and reveals differential neuronal biological ageing relevant for Parkinson’s disease susceptibilitySemantic proximity Read

Bacterially produced metabolites protect C. elegans neurons from degeneration.Semantic proximity Read

Functional Analysis of Late-Onset Alzheimer’s Disease Risk Genes in <i>Caenorhabditis elegans</i> Identifies Regulators of Neuronal AgingSemantic proximity Read

A novel multisystem approach uncovers conserved mitochondrial complex I disease phenotypes and suppressorsSemantic proximity Read

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson’s diseaseSemantic proximity Read

Investigating the Neuroprotective Effects of Vitamin E Against Oxidative Stress in the AWC Chemosensory Neurons of Caenorhabditis elegansSemantic proximity Read