Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system.

doi:10.1523/JNEUROSCI.1494-11.2012

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Article

Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jun 2012

Toth Marton Lorant, Melentijevic Ilija, Shah Leena, Bhatia Aatish, Lu Kevin, Talwar Amish, Naji Haaris, Ibanez-Ventoso Carolina, Ghose Piya, Jevince Angela, Xue Jian, Herndon Laura A, Bhanot Gyan, Rongo Chris, Hall David H, Driscoll Monica

Abstract excerpt

Caenorhabditis elegans is a powerful model for analysis of the conserved mechanisms that modulate healthy aging. In the aging nematode nervous system, neuronal death and/or detectable loss of processes are not readily apparent, but because dendrite restructuring and loss of synaptic integrity are hypothesized to contribute to human brain decline and dysfunction, we combined fluorescence microscopy and electron...

Topics

Age Factors
Aging
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Forkhead Transcription Factors
Green Fluorescent Proteins
Microscopy, Electron, Transmission

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitochondria

Mutation

Nervous System

Neurites

Neurons

Receptor, Insulin

Signal Transduction

Synapses

Touch

Source

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Identifiers

PMID: 22745480
DOI: 10.1523/JNEUROSCI.1494-11.2012
PMCID: PMC3427745

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