Article
Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans.
Cell metabolism - 3 Sept 2013
Liu Jie, Zhang Bi, Lei Haoyun, Feng Zhaoyang, Liu Jianfeng, Hsu Ao-Lin, Xu X Z Shawn
Abstract excerpt
Aging is characterized by a progressive decline in multiple physiological functions (i.e., functional aging). As animals age, they exhibit a gradual loss in motor activity, but the underlying mechanisms remain unclear. Here we approach this question in C. elegans by functionally characterizing its aging nervous system and muscles. We find that motor neurons exhibit a progressive functional decline, beginning in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.