Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans.

doi:10.1016/j.cmet.2013.08.007

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Article

Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans.

Cell metabolism - 3 Sept 2013

Liu Jie, Zhang Bi, Lei Haoyun, Feng Zhaoyang, Liu Jianfeng, Hsu Ao-Lin, Xu X Z Shawn

Abstract excerpt

Aging is characterized by a progressive decline in multiple physiological functions (i.e., functional aging). As animals age, they exhibit a gradual loss in motor activity, but the underlying mechanisms remain unclear. Here we approach this question in C. elegans by functionally characterizing its aging nervous system and muscles. We find that motor neurons exhibit a progressive functional decline, beginning in...

Topics

Acetylcholine
Aging
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Motor Activity
Mutation
Nervous System
Neurons
Receptor, Insulin
Synaptic Transmission
gamma-Aminobutyric Acid

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Identifiers

PMID: 24011074
DOI: 10.1016/j.cmet.2013.08.007
PMCID: PMC3811915

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