Article
Bacterially produced metabolites protect C. elegans neurons from degeneration.
PLoS biology - 1 Mar 2020
Urrutia Arles, García-Angulo Víctor A, Fuentes Andrés, Caneo Mauricio, Legüe Marcela, Urquiza Sebastián, Delgado Scarlett E, Ugalde Juan, Burdisso Paula, Calixto Andrea
Abstract excerpt
Caenorhabditis elegans and its cognate bacterial diet comprise a reliable, widespread model to study diet and microbiota effects on host physiology. Nonetheless, how diet influences the rate at which neurons die remains largely unknown. A number of models have been used in C. elegans as surrogates for neurodegeneration. One of these is a C. elegans strain expressing a neurotoxic allele of the mechanosensory...
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