Article

Centromere-specifying nucleosomes persist in aging mouse oocytes in the absence of nascent assembly

2023-05-18

Abstract excerpt

<h4>SUMMARY</h4> Centromeres direct genetic inheritance but are not themselves genetically encoded. Instead, centromeres are defined epigenetically by the presence of a histone H3 variant, CENP-A 1 . In cultured somatic cells, an established paradigm of cell cycle-coupled propagation maintains centromere identity: CENP-A is partitioned between sisters during replication and replenished by new assembly, which is...

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Literature Corpus work: 3a6e3096-774e-53f2-a7fd-0a8961b96761
DOI: 10.1101/2023.05.18.541332

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