Article

<i>Tex19.1</i> Regulates Acetylated SMC3 Cohesin and Prevents Aneuploidy in Mouse Oocytes

2017-02-07

Abstract excerpt

Age-dependent oocyte aneuploidy, a major cause of Down syndrome, is associated with declining sister chromatid cohesion in postnatal oocytes. Here we show that cohesion in postnatal mouse oocytes is regulated by Tex19.1 . We show that Tex19.1 -/- oocytes have defects in the maintenance of chiasmata, mis-segregate their chromosomes during meiosis, and transmit aneuploidies to the next generation. By reconstitutin...

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Literature Corpus work: f9444e88-47d4-5c67-84df-349754ed1770
DOI: 10.1101/102285

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