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Chromosome Ageing Occurs at the Primordial Follicle Stage in both Mouse and Human Oocytes

2025-07-18

Abstract excerpt

<h4>Summary</h4> Inherited aneuploidy is one of the most common causes of human genetic disease affecting approximately 20% of all human embryos and is the major cause of non-conception in older women. Inherited aneuploidies typically arise from meiotic chromosome segregation errors and are strongly affected by maternal age. Cohesin, a protein complex that mediates cohesion between sister chromatids, becomes depl...

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Literature Corpus work
5215749b-3fc2-52f2-8c98-376c503cc9bf
DOI
10.1101/2025.07.17.663489
Open publication

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Chromosome Ageing Occurs at the Primordial Follicle Stage in both Mouse and Human OocytesDOI 10.1101/2025.07.17.663489
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