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CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes

11 Nov 2021

Abstract excerpt

Abstract Proper chromosome segregation is essential to avoid aneuploidy, yet this process fails with increasing age in mammalian oocytes. Here we report a role for the scarcely described protein CENP-V in oocyte spindle formation and chromosome segregation. We show that depending on the oocyte maturation state, CENP-V localizes to centromeres, to microtubule organizing centers, and to spindle microtubules. We...

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PMID: 34764261
DOI: 10.1038/s41467-021-26826-3

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