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Article

Postovulatory Ageing of Mouse Oocytes in Vivo and Premature Centromere Separation and Aneuploidy

1 May 1998

Abstract excerpt

Two paramount observations exist regarding aneuploidy in human oocytes: its association with maternal age and its more frequent occurrence during meiosis I. Numerous experimental studies have shown that fertilization of postovulatory aged oocytes is coupled with reproductive failure and cytogenetic aberrations in embryos. However, the basic cytogenetic defect(s) of aged oocytes that causes these abnormalities has...

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PMID: 9603254
DOI: 10.1095/biolreprod58.5.1206

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