Article

Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable photoPROTACs

2019-06-17

Abstract excerpt

Off-target effects are persistent issues of modern inhibition-based therapies. By merging the strategies of photopharmacology and small molecule degraders, we introduce a novel concept for persistent spatiotemporal control of induced protein degradation that potentially prevents off-target toxicity. Building on the successful principle of bifunctional all-small molecule Proteolysis Targeting Chimeras (PROTAC...

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Literature Corpus work: d339401f-5ded-5085-86ce-90119648d353
DOI: 10.26434/chemrxiv.8281469.v2

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