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Article

Optical control of cell signaling by single-chain photoswitchable kinases.

Science (New York, N.Y.) - 24 Feb 2017

Zhou Xin X, Fan Linlin Z, Li Pengpeng, Shen Kang, Lin Michael Z

Abstract excerpt

Protein kinases transduce signals to regulate a wide array of cellular functions in eukaryotes. A generalizable method for optical control of kinases would enable fine spatiotemporal interrogation or manipulation of these various functions. We report the design and application of single-chain cofactor-free kinases with photoswitchable activity. We engineered a dimeric protein, pdDronpa, that dissociates in cyan...

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Identifiers

PMID: 28232577
DOI: 10.1126/science.aah3605
PMCID: PMC5589340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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