Article

RGS2 is an innate immune checkpoint for TLR4 and Gαq-mediated IFNγ generation and lung injury

2023-09-23

Abstract excerpt

<h4>Summary</h4> IFNγ, a type II interferon secreted by immune cells, augments tissue responses to injury following pathogenic infections leading to lethal acute lung injury (ALI). Alveolar macrophages (AM) abundantly express Toll-like receptor-4 and represent the primary cell type of the innate immune system in the lungs. A fundamental question remains whether AM generation of IFNg leads to uncontrolled innate r...

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Literature Corpus work: 3a30d49e-197e-55cd-b444-6534bbf795b2
DOI: 10.1101/2023.09.22.559016

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