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Article

cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2023

Shen Xuecheng, Sun Caiyu, Cheng Yeping, Ma Dapeng, Sun Yanlin, Lin Yueke, Zhao Yunxue, Yang Min, Jing Weiqiang, Cui Xiuling, Han Lihui

Abstract excerpt

Cyclic GMP-AMP synthase (cGAS), as a cytosolic DNA sensor, plays a crucial role in antiviral immunity, and its overactivation induces excess inflammation and tissue damage. Macrophage polarization is critically involved in inflammation; however, the role of cGAS in macrophage polarization during inflammation remains unclear. In this study, we demonstrated that cGAS was upregulated in the LPS-induced inflammatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36881861
DOI: 10.4049/jimmunol.2200351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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