Article
Interferon-γ constrains cytokine production of group 2 innate lymphoid cells.
Immunology - 1 Jan 2016
Kudo Fujimi, Ikutani Masashi, Seki Yoichi, Otsubo Takeshi, Kawamura Yuki I, Dohi Taeko, Oshima Kenshiro, Hattori Masahira, Nakae Susumu, Takatsu Kiyoshi, Takaki Satoshi
Abstract excerpt
Group 2 innate lymphoid cells (ILC2s) produce a significant amount of interleukin-5 (IL-5), which supports eosinophil responses in various tissues; they also produce IL-13, which induces mucus production and contributes to tissue repair or fibrosis. The ILC2s are activated by alarmins, such as IL-33 released from epithelia, macrophages and natural killer T (NKT) cells in response to infection and allergen...
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