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Article

Mecp2 Deficiency Disrupts Norepinephrine and Respiratory Systems in Mice

14 Dec 2005

Abstract excerpt

Rett syndrome is a severe X-linked neurological disorder in which most patients have mutations in the methyl-CpG binding protein 2 (MECP2) gene and suffer from bioaminergic deficiencies and life-threatening breathing disturbances. We used in vivo plethysmography, in vitro electrophysiology, neuropharmacology, immunohistochemistry, and biochemistry to characterize the consequences of the MECP2 mutation on...

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PMID: 16354910
DOI: 10.1523/jneurosci.4373-05.2005

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Mecp2 Deficiency Disrupts Norepinephrine and Respiratory Systems in MicePMID 16354910Read ↗

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Loss of MeCP2 leads to sleep deficits that are time-of-day dependent and worsen with sleep deprivationSemantic proximity Read ↗

Respiratory phenotypes are distinctly affected in mice with common Rett syndrome mutations MeCP2 T158A and R168X.Semantic proximity Read ↗

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