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Article

Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2stop mice.

Behavioural brain research - 30 Mar 2017

Zhou Huanhuan, Wu Wei, Zhang Ying, He Haiyang, Yuan Zhefeng, Zhu Zhiwei, Zhao Zhengyan

Abstract excerpt

RTT is a neurodevelopmental disorder characterized by growth regression, motor dysfunction, stereotypic hand movements, and autism features. Typical Rett syndrome (RTT) is predominantly caused by mutations in X-linked MeCP2 gene which encodes methyl-CpG-binding protein 2 (MeCP2). The brain-abundant MeCP2 protein mainly functions as a transcriptional regulator for neurodevelopment-associated genes. Specific...

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Source

Identifiers

PMID: 28093257
DOI: 10.1016/j.bbr.2017.01.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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