Article

Early AMPA receptor potentiation modifies synaptic maturation and disease progression in Rett models

2026-08-07

Abstract excerpt

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in MECP2 and characterized by impaired neuronal maturation and synaptic dysfunction. Positive allosteric modulators of AMPA receptors (AMPAR-PAMs) have shown therapeutic promise in RTT models, but the determinants of treatment responsiveness remain unclear. Here, we evaluated the clinically advanced AMPAR-PAM CX1632 in Mecp2 -null ma...

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Literature Corpus work: a3f7ec9c-565a-5f3a-94b3-cbf57c9d1903
DOI: 10.64898/2026.08.04.742773

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