Article

Mycobacterium tuberculosis reactivates HIV via exosomes mediated resetting of cellular redox potential and bioenergetics

2019-05-07

Abstract excerpt

The synergy between Mycobacterium tuberculosis ( Mtb ) and HIV-1 interferes with therapy and facilitates pathogenesis of both human pathogens. Fundamental mechanisms by which Mtb exacerbates HIV-1 are not clear. Here, we show that exosomes secreted by macrophages infected with Mtb , including drug-resistant clinical strains, reactivate HIV-1 by inducing oxidative stress. Mechanistically, Mtb -specific exosome...

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Literature Corpus work: 39952b2f-a94d-56bf-9bb4-1b1866ed10c4
DOI: 10.1101/629048

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