Article

Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

2021-04-21

Abstract excerpt

A fundamental challenge in HIV eradication is to understand how the virus establishes latency, maintains stable cellular reservoirs, and promotes rebound upon interruption of antiretroviral treatment (ART). Here, we discovered an unexpected role of the ubiquitous gasotransmitter hydrogen sulfide (H 2 S) in HIV latency and reactivation. We show that reactivation of HIV-1 is associated with down-regulation of the k...

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Literature Corpus work: f0d55785-e611-5542-b2e1-c96d72877b58
DOI: 10.1101/2021.04.21.440760

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