Article

HSP60 controls mitochondrial ATP generation for optimal virus-specific IL-21-producing CD4 and cytotoxic CD8 memory T cell responses

2024-08-21

Abstract excerpt

<title>Abstract</title> We have shown that virus-specific CD4 and CD8 memory T cells (TM) induce autophagy after T cell receptor (TCR) engagement to provide free glutamine and fatty acids, including in people living with HIV-1 (PLWH). These nutrients fuel mitochondrial ATP generation through glutaminolysis and fatty acid oxidation (FAO) pathways, to fulfill the bioenergetic demands for optimal IL-21 and cytoto...

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Literature Corpus work: 32d4a28f-3bc9-53ae-beca-eabb3cd5e585
DOI: 10.21203/rs.3.rs-4601043/v1

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