Back to search

Article

Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4 <sup>+</sup> T-cells

2024-12-22

Abstract excerpt

<h4>Summary</h4> Cytotoxic T-lymphocytes (CTL) exert sustained pressure on reservoirs of HIV-infected cells that persist through years of antiretroviral therapy (ART). This selects for latently infected cells, but also potentially for cells that express HIV but possess intrinsic CTL resistance. We demonstrate that such resistance exists in HIV-infected CD4 + T-cells that survive rigorous CTL attack and map CTL s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2771596b-8357-55e6-a47d-b3a395f5b863
DOI
10.1101/2024.12.22.629960
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4 <sup>+</sup> T-cellsDOI 10.1101/2024.12.22.629960
A single-cell atlas reveals shared and distinct immune responses and metabolism during SARS-CoV-2 and HIV-1 infectionsSemantic proximity
Omic Technologies in HIV: Searching Transcriptional Signatures Involved in Long-Term Non-Progressor and HIV Controller Phenotypes.Semantic proximity
Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle InfectionSemantic proximity
<sup>13</sup> C tracer analysis reveals the landscape of metabolic checkpoints in human CD8 <sup>+</sup> T cell differentiationSemantic proximity
Host genetic and immune factors drive evasion of HIV-1 pathogenesis in viremic non-progressors.Semantic proximity
An HIV-induced mechanism for T cell quiescence and proviral latencySemantic proximity
CD8+ T cells promote HIV latency by remodeling CD4+ T cell metabolism to enhance their survival, quiescence, and stemnessSemantic proximity
Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infectionSemantic proximity
Metabolome and transcriptome analysis of oral mucosa of HIV+ patients reveal a role for polyamine metabolic pathway in T cell dysfunctionSemantic proximity
Multi-Omics Clustering Differentiates the Total and Intact HIV Reservoirs and Related Host Immune MechanismsSemantic proximity
Global transcriptomic characterization of T cells in individuals with chronic HIV-1 infectionSemantic proximity
Single cell multi-omics reveals early elevated function and multiple fates within human progenitor exhausted CD8 <sup>+</sup> T cellsSemantic proximity
Select a neighboring publication to make it the new centre.