Article

Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in Mouse Alzheimer Model

2025-01-05

Abstract excerpt

<h4>ABSTRACT</h4> ArfGAP, with dual PH domain-containing protein 1/Centaurin-α1 (ADAP1CentA1), is a brain-enriched and highly conserved Arf6 GTPase-activating and Ras-anchoring protein. ADAP1 is involved in dendritic outgrowth and arborization, synaptogenesis, and axonal polarization by regulating the dynamics of the actin cytoskeleton. An increased level of ADAP1 and its association with amyloid plaques in the h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3990a5af-b965-5273-b8b6-1f0b1e13ce6b
DOI: 10.1101/2025.01.05.630617

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in Mouse Alzheimer ModelDOI 10.1101/2025.01.05.630617Read

Functional Analysis of Late-Onset Alzheimer’s Disease Risk Genes in <i>Caenorhabditis elegans</i> Identifies Regulators of Neuronal AgingSemantic proximity Read

Nodes and biological processes identified on the basis of network analysis in the brain of the senescence accelerated mice as an Alzheimer's disease animal modelSemantic proximity Read

Association of GLOD4 with Alzheimer’s Disease in Humans and MiceSemantic proximity Read

The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged miceSemantic proximity Read

Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer’s DiseaseSemantic proximity Read

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived NeuronsSemantic proximity Read

Crtc1 Activates a Transcriptional Program Deregulated at Early Alzheimer's Disease-Related StagesSemantic proximity Read

Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer’s Disease-related endosomal and synaptic dysfunction with cholinergic neurodegenerationSemantic proximity Read

The lncRNA <i>Neat1</i> is associated with astrocyte reactivity and memory deficits in a mouse model of Alzheimer’s diseaseSemantic proximity Read

The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice.Semantic proximity Read

Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic modelsSemantic proximity Read

Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein.Semantic proximity Read