Article

The lncRNA <i>Neat1</i> is associated with astrocyte reactivity and memory deficits in a mouse model of Alzheimer’s disease

2023-05-03

Abstract excerpt

Dysregulation of long non-coding RNAs (lncRNAs) have been associated with Alzheimer’s disease (AD). However, the functional role of lncRNAs in AD remains unclear. Here, we report a crucial role for the lncRNA Neat1 in astrocyte dysfunction and memory deficits associated with AD. Transcriptomics analysis show abnormally high expression levels of NEAT1 in the brains of AD patients relative to aged-matched healthy...

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Literature Corpus work: e933bb3a-02fd-5eaf-b2bc-85463e8ffd81
DOI: 10.1101/2023.05.03.539260

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