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Article

Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10

8 Oct 2020

Abstract excerpt

Viruses employ multiple strategies to inhibit host mRNA nuclear export. Distinct to the generally nonselective inhibition mechanisms, ORF10 from gammaherpesviruses inhibits mRNA export in a transcript-selective manner by interacting with Rae1 (RNA export 1) and Nup98 (nucleoporin 98). We now report the structure of ORF10 from MHV-68 (murine gammaherpesvirus 68) bound to the Rae1-Nup98 heterodimer, thereby...

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PMID: 33033226
DOI: 10.1073/pnas.2007774117

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