Article

Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic target

2024-01-18

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 and its emerging variants pose continuing threats to public health, necessitating further research into detailed infection mechanisms and broad-spectrum antiviral therapies. SARS-CoV-2 assembles at the ER–Golgi intermediate compartment (ERGIC), where the viral membrane (M) protein highly accumulates to act as the central driver of the viral morphogenesis. However, which host...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8ca1648-6c2c-5b78-a74c-e416a2cac3a2
DOI: 10.21203/rs.3.rs-3812840/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic targetDOI 10.21203/rs.3.rs-3812840/v1Read

Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic targetSemantic proximity Read

Targeting ARF4-mediated intracellular transport as broad-spectrum antiviralsSemantic proximity Read

ARF6 is a host factor for SARS-CoV-2 infection <i>in vitro</i>Semantic proximity Read

Enhanced binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pathogenesisSemantic proximity Read

Decoupling SARS-CoV-2 ORF6 localization and interferon antagonismSemantic proximity Read

The comprehensive SARS-CoV-2 ‘hijackome’ knowledge base— reveals significant changes in host cell protein expression and activation by multiple SARS-CoV-2 variantsSemantic proximity Read

Decoupling SARS-CoV-2 ORF6 localization and interferon antagonismSemantic proximity Read

SARS-CoV-2 and the Host Cell: A Tale of InteractionsSemantic proximity Read

The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus EntrySemantic proximity Read

ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egressSemantic proximity Read

Atlas of interactions between SARS-CoV-2 macromolecules and host proteinsSemantic proximity Read

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replicationSemantic proximity Read