Article

SARS-CoV-2 ORF6 disturbs nucleocytoplasmic trafficking to advance the viral replication

2021-02-24

Abstract excerpt

<h4>ABSTRACT</h4> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the coronavirus disease 2019 pandemic. ORF6 is known to antagonize the interferon signaling by inhibiting the nuclear translocation of STAT1. Here we show that ORF6 acts as a virulence factor through two distinct strategies. First, ORF6 directly interacts with STAT1 in an IFN-independent manner to inhibit i...

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Literature Corpus work: 2b94d7c8-4506-5de2-ad53-f1a8f9322b27
DOI: 10.1101/2021.02.24.432656

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