Natural selection links immune-gene variation to blood virome burden in indigenous Orang Asli from tropical Southeast Asia

Abstract excerpt

<title>Abstract</title> <p>Pathogen-rich tropical rainforest provides natural setting to investigate how natural selection shapes human immunity. The Orang Asli, among the oldest indigenous groups in Southeast Asia have experienced long-term exposure to diverse infectious agents and ecological stressors. We profile immune-gene variation in five Orang Asli populations using deep whole-genome sequencing, together w...

Topics

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• Adaptation, Physiological
• Genetic Variation
• Genetics, Population
• Genome-Wide Association Study
• Immunity, Innate
• Neanderthals
• Polymorphism, Single Nucleotide
• Selection, Genetic

Identifiers and source

Literature Corpus work

396ed1ae-883c-5252-8749-042aacd511f2

DOI

10.21203/rs.3.rs-8552878/v1