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Article

Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jan 2023

Lea Amanda J, Garcia Angela, Arevalo Jesusa, Ayroles Julien F, Buetow Kenneth, Cole Steve W, Eid Rodriguez Daniel, Gutierrez Maguin, Highland Heather M, Hooper Paul L, Justice Anne, Kraft Thomas, North Kari E, Stieglitz Jonathan, Kaplan Hillard, Trumble Benjamin C, Gurven Michael D

Abstract excerpt

A growing body of work has addressed human adaptations to diverse environments using genomic data, but few studies have connected putatively selected alleles to phenotypes, much less among underrepresented populations such as Amerindians. Studies of natural selection and genotype-phenotype relationships in underrepresented populations hold potential to uncover previously undescribed loci underlying evolutionarily...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36574663
DOI: 10.1073/pnas.2207544120
PMCID: PMC9910614

Genes

ABCA1
ANXA6
MUC21
MUC22
PSD4
TOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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