Article

TIF1γ drives oral cancer recurrence by the transcriptional regulation of self-renewal genes, such as <i>HES1</i>

2025-12-04

Abstract excerpt

<h4>ABSTRACT</h4> TIF1γ is an E3 ubiquitin ligase and key mediator of the noncanonical TGF-β signaling pathway. Initially characterized for its developmental functions, TIF1γ is essential for maintaining the pluripotency of adult stem cells, including long-term hematopoietic stem cells. Although TGF-β signaling contributes to cancer progression and recurrence, TIF1γ has traditionally been regarded as a tumor supp...

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Literature Corpus work: 39638042-f583-5690-a85b-7be3899d4dac
DOI: 10.64898/2025.12.02.691793

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