Article
Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma.
International journal of oral science - 29 Feb 2024
Xiong Gan, Xie Nan, Nie Min, Ling Rongsong, Yun Bokai, Xie Jiaxiang, Ren Linlin, Huang Yaqi, Wang Wenjin, Yi Chen, Zhang Ming, Xu Xiuyun, Zhang Caihua, Zou Bin, Zhang Leitao, Liu Xiqiang, Huang Hongzhang, Chen Demeng, Cao Wei, Wang Cheng
Abstract excerpt
Ameloblastoma is a benign tumor characterized by locally invasive phenotypes, leading to facial bone destruction and a high recurrence rate. However, the mechanisms governing tumor initiation and recurrence are poorly understood. Here, we uncovered cellular landscapes and mechanisms that underlie tumor recurrence in ameloblastoma at single-cell resolution. Our results revealed that ameloblastoma exhibits five...
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