Article

<i>HOTAIR</i> primes the Ewing sarcoma family of tumors for tumorigenesis via epigenetic dysregulation involving LSD1

2018-01-08

Abstract excerpt

The EWS-FLI1 fusion protein drives oncogenesis in the Ewing sarcoma family of tumors (ESFT) in humans, but its toxicity in normal cells requires additional cellular events for oncogenesis. We show that the lncRNA HOTAIR maintains cell viability in the presence of EWS-FLI1 and redirects epigenetic regulation in ESFT. HOTAIR is consistently overexpressed in ESFTs and is not driven by EWS-FLI1. Repression of HOTAI...

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Literature Corpus work: ba5c7aa1-a4c9-5d49-8e69-f0cc5402b8a8
DOI: 10.1101/244558

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