Article
Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer.
The Journal of clinical investigation - 1 Jun 2020
Xing Manjie, Ooi Wen Fong, Tan Jing, Qamra Aditi, Lee Po-Hsien, Li Zhimei, Xu Chang, Padmanabhan Nisha, Lim Jing Quan, Guo Yu Amanda, Yao Xiaosai, Amit Mandoli, Ng Ley Moy, Sheng Taotao, Wang Jing, Huang Kie Kyon, Anene-Nzelu Chukwuemeka George, Ho Shamaine Wei Ting, Ray Mohana, Ma Lijia, Fazzi Gregorio, Lim Kevin Junliang, Wijaya Giovani Claresta, Zhang Shenli, Nandi Tannistha, Yan Tingdong, Chang Mei Mei, Das Kakoli, Isa Zul Fazreen Adam, Wu Jeanie, Poon Polly Suk Yean, Lam Yue Ning, Lin Joyce Suling, Tay Su Ting, Lee Ming Hui, Tan Angie Lay Keng, Ong Xuewen, White Kevin, Rozen Steven George, Beer Michael, Foo Roger Sik Yin, Grabsch Heike Irmgard, Skanderup Anders Jacobsen, Li Shang, Teh Bin Tean, Tan Patrick
Abstract excerpt
Transcriptional reactivation of telomerase catalytic subunit (TERT) is a frequent hallmark of cancer, occurring in 90% of human malignancies. However, specific mechanisms driving TERT reactivation remain obscure for many tumor types and in particular gastric cancer (GC), a leading cause of global cancer mortality. Here, through comprehensive genomic and epigenomic analysis of primary GCs and GC cell lines, we...
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