Article
Stabilization of HDAC1 via TCL1-pAKT-CHFR axis is a key element for NANOG-mediated multi-resistance and stem-like phenotype in immune-edited tumor cells.
Biochemical and biophysical research communications - 10 Sept 2018
Woo Seon Rang, Lee Hyo-Jung, Oh Se Jin, Kim Suyeon, Park Sang-Hyo, Lee Jaeyoon, Song Kwon-Ho, Kim Tae Woo
Abstract excerpt
Cancer immunoediting enriches NANOG expression in tumor cells, resulting in multi-drug resistance and stem-like phenotypes. We previously demonstrated that these NANOG-associated phenotypes are promoted through HDAC1 transcriptional upregulation. In this study, we identified that NANOG also contributes to the stabilization of HDAC1 protein through the AKT signaling pathway. NANOG-AKT axis leads to...
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