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Article

Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence

22 May 2014

Abstract excerpt

Hyperactivation of the Wingless-type (Wnt)/β-catenin pathway promotes tumor initiation, tumor growth and metastasis in various tissues. Although there is evidence for the involvement of Wnt/β-catenin pathway activation in salivary gland tumors, the precise mechanisms are unknown. Here we report for the first time that downregulation of the Wnt inhibitory factor 1 (WIF1) is a widespread event in salivary gland...

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PMID: 24853424
DOI: 10.1038/cddis.2014.219

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