Article

Targeted regeneration of post-radiation epithelium without promoting cancer recurrence

2026-02-19

Abstract excerpt

<title>Abstract</title> <p>Cancer radiotherapy inevitably damages normal tissues, yet therapeutic activation of pro-survival or regenerative pathways frequently increases the risk of cancer recurrence. Strategies that selectively restore normal tissue without fueling malignant regrowth remain largely undefined. Using the slow dividing yet radio-responsive salivary gland and adjacent oral squamous cell carcinoma (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 55e3e0d3-a138-5f30-bdce-6beb790fc19c
DOI: 10.21203/rs.3.rs-7320272/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeted regeneration of post-radiation epithelium without promoting cancer recurrenceDOI 10.21203/rs.3.rs-7320272/v1Read

scRNAseq of healthy and irradiated mouse parotid glands highlights crosstalk between immune and secretory cells during chronic injurySemantic proximity Read

Salivary glands regenerate after radiation injury through SOX2‐mediated secretory cell replacementSemantic proximity Read

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survivalSemantic proximity Read

Diverse progenitor cells preserve salivary gland ductal architecture after radiation induced damageSemantic proximity Read

Extracellular Vesicles of Salivary Mesenchymal Stem Cells Mitigate Acute Irradiation Injury: Use of an ex-vivo organotypic human slice tissue culture as a disease modelSemantic proximity Read

Chronic Phenotypes Underlying Radiation-Induced Salivary Gland Dysfunction.Semantic proximity Read

Salivary gland stem cells: A review of development, regeneration and cancerSemantic proximity Read

Salivary Gland Cancer Patient-Derived Xenografts Enable Characterization of Cancer Stem Cells and New Gene Events Associated with Tumor Progression.Semantic proximity Read

Purification and Ex Vivo Expansion of Fully Functional Salivary Gland Stem CellsSemantic proximity Read

Salivary Gland Cancers: Biology and Molecular Targets for TherapySemantic proximity Read

Macrophages prime KRT14+ ductal progenitor cells to drive regeneration in the salivary gland following radiation-induced injurySemantic proximity Read

A Pilot Study to Assess the Salivary Gland Regenerative Potential of Bone Marrow Mesenchymal Stromal Cells from Treated Head and Neck Cancer PatientsSemantic proximity Read