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Article

Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

16 May 2007

Abstract excerpt

BACKGROUND: Despite their distinct origins, human embryonic stem (hES) and embryonic carcinoma (hEC) cells share a number of similarities such as surface antigen expression, growth characteristics, the ability to either self-renew or differentiate, and control of the undifferentiated state by the same core transcription factors. To obtain further insights into the regulation of self-renewal, we have silenced...

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PMID: 17506876
DOI: 10.1186/1471-213x-7-46

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