Article

<i>MECP2</i> -mutant marmosets exhibit primate-specific phenotypes of Rett syndrome

2026-06-29

Abstract excerpt

We used genome editing to generate MECP2 -knockout marmosets and establish a new primate model for Rett syndrome (RTT), a neurodevelopmental disorder. MRI analysis of this marmoset model revealed diminished cortico-cortical connections, particularly those originating in the prefrontal cortex. Detailed histological analysis revealed reduced dendritic arborization and synaptic density, particularly in the upper lay...

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Literature Corpus work: 3b5372ba-015b-5153-9504-8c14d13c1bdf
DOI: 10.64898/2026.06.26.734672

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