Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.

Brain : a journal of neurology - 1 Sept 2012

Robinson Lianne, Guy Jacky, McKay Leanne, Brockett Emma, Spike Rosemary C, Selfridge Jim, De Sousa Dina, Merusi Cara, Riedel Gernot, Bird Adrian, Cobb Stuart R

Abstract excerpt

Rett syndrome is a neurological disorder caused by mutation of the X-linked MECP2 gene. Mice lacking functional Mecp2 display a spectrum of Rett syndrome-like signs, including disturbances in motor function and abnormal patterns of breathing, accompanied by structural defects in central motor areas and the brainstem. Although routinely classified as a neurodevelopmental disorder, many aspects of the mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Cerebral Cortex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Hand Strength

Share to Methyl-CpG-Binding Protein 2

Share to Neurons

Share to Rett Syndrome

Share to Rotarod Performance Test

Source

Open in PubMed Open full text

Identifiers

PMID: 22525157
DOI: 10.1093/brain/aws096
PMCID: PMC3437019

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.PMID 22525157Read ↗

Reversal of neurological defects in a mouse model of Rett syndrome.Semantic proximity Read ↗

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome.Semantic proximity Read ↗

Rett syndrome treatment in mouse models: searching for effective targets and strategies.Semantic proximity Read ↗

Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation.Semantic proximity Read ↗

The story of Rett syndrome: from clinic to neurobiology.Semantic proximity Read ↗

Deciphering MECP2-associated disorders: disrupted circuits and the hope for repair.Semantic proximity Read ↗

A comprehensive longitudinal study of magnetic resonance imaging identifies novel features of the Mecp2 deficient mouse brain.Semantic proximity Read ↗

Mecp2 deletion results in profound alterations of developmental and adult functional connectivitySemantic proximity Read ↗

Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome.Semantic proximity Read ↗

Cell-Type-Specific Gene Inactivation and In Situ Restoration via Recombinase-Based Flipping of Targeted Genomic Region.Semantic proximity Read ↗

Unconventional transcriptional response to environmental enrichment in a mouse model of Rett syndrome.Semantic proximity Read ↗

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.