Article
A comprehensive longitudinal study of magnetic resonance imaging identifies novel features of the Mecp2 deficient mouse brain.
Neurobiology of disease - 1 May 2023
Carli Sara, Chaabane Linda, De Rocco Giuseppina, Albizzati Elena, Sormonta Irene, Calligaro Stefano, Bonizzi Pietro, Frasca Angelisa, Landsberger Nicoletta
Abstract excerpt
Rett syndrome (RTT) is a X-linked neurodevelopmental disorder which represents the leading cause of severe incurable intellectual disability in females worldwide. The vast majority of RTT cases are caused by mutations in the X-linked MECP2 gene, and preclinical studies on RTT largely benefit from the use of mouse models of Mecp2, which present a broad spectrum of symptoms phenocopying those manifested by RTT...
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