Back to search

Article

The genetic paradigms of dietary restriction fail to extend life span in <i>cep-1(gk138)</i> mutant of <i>C. elegans</i> p53 due to possible background mutations

2020-07-10

Abstract excerpt

Dietary restriction (DR) increases life span and improves health in most model systems tested, including non-human primates. In C. elegans , as in other models, DR leads to reprogramming of metabolism, improvements in mitochondrial health, large changes in gene expression, including increase in expression of cytoprotective genes, better proteostasis etc. Understandably, multiple global transcriptional regulators...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
39417e5d-d881-5f11-9e63-9d2abed5bf01
DOI
10.1101/2020.07.09.195503
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The genetic paradigms of dietary restriction fail to extend life span in <i>cep-1(gk138)</i> mutant of <i>C. elegans</i> p53 due to possible background mutationsDOI 10.1101/2020.07.09.195503
The genetic paradigms of dietary restriction fail to extend life span in cep-1(gk138) mutant of C. elegans p53 due to possible background mutations.Semantic proximity
p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.Semantic proximity
Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type <i>C. elegans</i> strainsSemantic proximity
CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants.Semantic proximity
Worms under stress: C. elegans stress response and its relevance to complex human disease and agingSemantic proximity
Genetic mapping of lifespan and mitochondrial stress response in <i>C. elegans</i>Semantic proximity
Impaired p53/CEP-1 is associated with lifespan extension through an age-related imbalance in the energy metabolism of C. elegans.Semantic proximity
Molecular mechanisms underlying genotype-dependent responses to dietary restriction.Semantic proximity
The effects of p53 on whole organism longevity are mediated by autophagy.Semantic proximity
Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.Semantic proximity
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.Semantic proximity
Genetic mapping of lifespan and mitochondrial stress response in C. elegansSemantic proximity
Select a neighboring publication to make it the new centre.