Article
The effects of p53 on whole organism longevity are mediated by autophagy.
Autophagy - 1 Oct 2008
Tavernarakis Nektarios, Pasparaki Angela, Tasdemir Ezgi, Maiuri Maria Chiara, Kroemer Guido
Abstract excerpt
The tumor suppressor protein p53 has a major impact on organismal aging. Recently it has become clear that p53 not only controls DNA damage responses, senescence and apoptosis but also plays a major role in the control of autophagy. Thus, deletion, depletion, or inhibition of p53 induces autophagy in human, mouse and nematode cells. We therefore tested the hypothesis that the mutation of the p53 orthologue CEP-1...
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