Article
Molecular mechanisms underlying genotype-dependent responses to dietary restriction.
Aging cell - 1 Dec 2013
Schleit Jennifer, Johnson Simon C, Bennett Christopher F, Simko Marissa, Trongtham Natalie, Castanza Anthony, Hsieh Edward J, Moller Richard M, Wasko Brian M, Delaney Joe R, Sutphin George L, Carr Daniel, Murakami Christopher J, Tocchi Autumn, Xian Bo, Chen Weiyang, Yu Tao, Goswami Sarani, Higgins Sean, Holmberg Mollie, Jeong Ki-Soo, Kim Jin R, Klum Shannon, Liao Eric, Lin Michael S, Lo Winston, Miller Hillary, Olsen Brady, Peng Zhao J, Pollard Tom, Pradeep Prarthana, Pruett Dillon, Rai Dilreet, Ros Vanessa, Singh Minnie, Spector Benjamin L, Vander Wende Helen, An Elroy H, Fletcher Marissa, Jelic Monika, Rabinovitch Peter S, MacCoss Michael J, Han Jing-Dong J, Kennedy Brian K, Kaeberlein Matt
Abstract excerpt
Dietary restriction (DR) increases lifespan and attenuates age-related phenotypes in many organisms; however, the effect of DR on longevity of individuals in genetically heterogeneous populations is not well characterized. Here, we describe a large-scale effort to define molecular mechanisms that underlie genotype-specific responses to DR. The effect of DR on lifespan was determined for 166 single gene deletion...
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