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Article

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.

Aging cell - 1 Feb 2011

Mouchiroud Laurent, Molin Laurent, Kasturi Prasad, Triba Mohamed N, Dumas Marc Emmanuel, Wilson Marieangela C, Halestrap Andrew P, Roussel Damien, Masse Ingrid, Dallière Nicolas, Ségalat Laurent, Billaud Marc, Solari Florence

Abstract excerpt

Dietary restriction (DR) is the most universal intervention known to extend animal lifespan. DR also prevents tumor development in mammals, and this effect requires the tumor suppressor PTEN. However, the metabolic and cellular processes that underly the beneficial effects of DR are poorly unders...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21040400
DOI: 10.1111/j.1474-9726.2010.00640.x

Genes

PTEN
HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21040400-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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