Article

Humanization of the mouse telomerase gene reset telomeres to human length

2024-01-05

Abstract excerpt

<title>Abstract</title> <p>Telomeres undergo shortening with each cell division, serving as biomarkers of human aging, which is characterized by short telomeres and restricted telomerase expression in adult tissues. Contrarily, mice, featuring their longer telomeres and widespread telomerase activity, present limitations as models for understanding telomere-related human biology and diseases. To bridge this gap,...

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Literature Corpus work: 390aa719-24be-5cff-822b-2f231b4c6a29
DOI: 10.21203/rs.3.rs-3617723/v1

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