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Article

Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice.

Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2004

Erdmann Natalie, Liu Yie, Harrington Lea

Abstract excerpt

Telomerase is a ribonucleoprotein containing an essential telomerase RNA template and telomerase reverse transcriptase (TERT) that maintains telomeres. The dosage requirements for mammalian TERT in telomere length homeostasis are not known, but are of importance in cellular senescence, stem cell renewal, and cancer. Here, we characterize telomere maintenance and function upon successive breeding of mice deficient...

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Identifiers

PMID: 15079066
DOI: 10.1073/pnas.0401580101
PMCID: PMC395926

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice.PMID 15079066Read ↗

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