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Article

Telomere length is inherited with resetting of the telomere set-point.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2010

Chiang Y Jeffrey, Calado Rodrigo T, Hathcock Karen S, Lansdorp Peter M, Young Neal S, Hodes Richard J

Abstract excerpt

We have studied models of telomerase haploinsufficiency in humans and mice to analyze regulation of telomere length and the significance of "set points" in inheritance of telomere length. In three families with clinical syndromes associated with short telomeres resulting from haploinsufficient mutations in TERT, the gene encoding telomerase reverse transcriptase, we asked whether restoration of normal genotypes...

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Identifiers

PMID: 20479226
DOI: 10.1073/pnas.0913125107
PMCID: PMC2890496

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Telomere length is inherited with resetting of the telomere set-point.PMID 20479226Read ↗

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Humanization of the mouse telomerase gene reset telomeres to human lengthSemantic proximity Read ↗

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Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes.Semantic proximity Read ↗

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Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.Semantic proximity Read ↗

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