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Telomouse—a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

23 Oct 2023

Abstract excerpt

Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell proliferation. Maintaining optimal telomere length in the germline and throughout life limits the risk of cancer and enables healthy aging. Telomeres in the house mouse, Mus musculus, are about five times longer than human telomeres, limiting the use of this common laboratory animal for studying the contribution of telomere...

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PMID: 37872177
DOI: 10.1038/s41467-023-42534-6

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