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Telomere length is an epigenetic trait - Implications for the use of telomerase-deficient organisms to model human disease.

Disease models & mechanisms - 1 Mar 2024

Henriques Catarina M, Ferreira Miguel Godinho

Abstract excerpt

Telomere length, unlike most genetic traits, is epigenetic, in the sense that it is not fully coded by the genome. Telomeres vary in length and randomly assort to the progeny leaving some individuals with longer and others with shorter telomeres. Telomerase activity counteracts this by extending telomeres in the germline and during embryogenesis but sizeable variances remain in telomere length. This effect is...

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Identifiers

PMID: 38441152
DOI: 10.1242/dmm.050581
PMCID: PMC10941657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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