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Human Specific Regulation of the Telomerase Reverse Transcriptase Gene

28 Jun 2016

Abstract excerpt

Telomerase, regulated primarily by the transcription of its catalytic subunit telomerase reverse transcriptase (TERT), is critical for controlling cell proliferation and tissue homeostasis by maintaining telomere length. Although there is a high conservation between human and mouse TERT genes, the regulation of their transcription is significantly different in these two species. Whereas mTERT expression is widely...

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PMID: 27367732
DOI: 10.3390/genes7070030

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